StuartParks-Log

StuartParks-Log

Article Outlined: __Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)__-[|DOI]

Abstract:

 * Introduces the concept of platelet rich plasma, and they various ways it can be classified. These classifications are based on both the leucocyte and fibrin content of the plasma.

History and techniques:

 * The original uses of plasma are discussed. The primary use was to prevent or reverse hemorrhaging in patients.
 * The time frame for newer applications are reviewed. Techniques like healing stimulation and wound sealing are introduced.
 * The article goes farther into newer applications, and the research that was inspired by the idea of what PRP can do.
 * Now the technique of recovering the PRP is covered. The process of centrifuging the collected blood and pipetting off the supernatant to concentrate the plasma is explained.

Definition of relevant parameters and classification:

 * The opening paragraph opens with the issues of manual preparation of PRP. It details how inconsistent procedures yielded varying results. This introduced the need for an automated, consistent process.
 * The next few paragraphs detail how the automated procedure is worked out, with all of the steps laid out for the reader to explore.
 * These steps are then explained to be the guidelines that separate the various classifications of PRP.

Automated protocols for P-PRP: plasmapheresis with a laboratory cell separator and Vivostat PRF:

 * These paragraphs show us how the original ways of collecting PRP were inefficient, as the methods lead to a non-optimally concentrated plasma sample.
 * Many ways to collect P-PRP are discussed, with the main one being delved into to discuss many handling problems, as they introduce error with each measurement.
 * As the article continues, it goes on about various methods of collecting the various types of PRP.

Leucocyte- and platelet-rich fibrin (L-PRF) concentrates: Choukroun's PRF:

 * The article then gets into its main object; Choukroun’s method of extracting and manipulationg PRP.
 * The additives in this technique allow for the blood to slowly coagulate, and for scablike structures of wound-sites.
 * The next few paragraphs discuss which classification of PRP is the most easily accessible, and why it should be used.

Conclusions:

 * The object of the article was to show the path of PRP, where we are now with the technology, and what the future might hold for the advancement of medicine.
 * More clarification on what was meant to be learned from the article (classification, processing, techniques…) are repeated.